Pfizer says FDA approves arthritis drug Xeljanz

NEW YORK (AP) — Pfizer says the Food and Drug Administration approved its rheumatoid arthritis pill Xeljanz (ZEL’jans), seen as potential big seller for the world’s largest pharmaceutical company.

Pfizer Inc. says the FDA approved Xeljanz as a treatment for moderate to severe rheumatoid arthritis in patients who can’t take methotrexate or haven’t been helped by it. Xeljanz is intended to slow the progression of the disease. The approval comes about two weeks sooner than expected.

Xeljanz, or tofacitinib, is the first rheumatoid arthritis treatment from a new class of pain medications called JAK inhibitors. The drugs interfere with enzymes that contribute to tissue inflammation.

Rheumatoid arthritis is a major area of research for drug companies because it is a chronic condition, meaning patients will likely take the drugs regularly for a long time.

Diseases/Conditions News Headlines – Yahoo! News

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Exclusive - Amazon to win EU e-book pricing tussle with Apple

BRUSSELS (Reuters) - European Union regulators are to end an antitrust probe into e-book prices by accepting an offer by Apple and four publishers to ease price restrictions on Amazon, two sources said on Tuesday.

That decision would hand online retailer Amazon a victory in its attempt to sell e-books cheaper than rivals in the fast-growing market publishers hope will boost revenue and increase customer numbers.

"Faced with years of court battles and uncertainty I can understand why some of these guys decided to fold their cards and take the whipping," said Mark Coker, founder of Smashwords, an ebook publisher and distributor that works with Apple.

"It's certainly another win for Amazon," he added. "I have not seen the terms of the final settlement, but my initial reaction is that it places restrictions on what publishers can do, slowing them down just when they need to be more nimble."

A spokesman at the EU Commission said its investigation was not yet finished. Amazon and Apple declined to comment.

In September, Apple and the publishers offered to let retailers set prices or discounts for a period of two years, and also to suspend "most-favored nation" contracts for five years.

Such clauses bar Simon & Schuster, News Corp. unit HarperCollins, Lagardere SCA's Hachette Livre and Verlagsgruppe Georg von Holtzbrinck, the owner of German company Macmillan, from making deals with rival retailers to sell e-books more cheaply than Apple.

The agreements, which critics say prevent Amazon and other retailers from undercutting Apple's charges, sparked an investigation by the European Commission in December last year.

Pearson Plc's Penguin group, which is also under investigation, did not take part in the offer.

The EU antitrust authority, which in September asked for feedback from rivals and consumers about the proposal, has not asked for more concessions, said one of sources.

"The Commission is likely to accept the offer and announce its decision next month," the source said on Tuesday.

Antoine Colombani, spokesman for competition policy at the European Commission, said: "We have launched a market test in September and our investigation is still ongoing."

Amazon declined to comment, while Apple did not respond to an email seeking comment.

Companies found guilty of breaching EU rules could be fined up to 10 percent of their global sales, which in Apple's case could reach $15.6 billion, based on its 2012 fiscal year.

AGGREGATE PRICING

UBS analysts estimate that e-books account for about 30 percent of the U.S. book market and 20 percent of sales in Britain but are minuscule elsewhere. When Amazon launched its Kindle e-reader, it charged $9.99 per book.

Apple's agency model let publishers set prices in return for a 30 percent cut to the maker of iPhone and iPad.

The U.S. Department of Justice is investigating e-book prices. HarperCollins, Simon & Schuster and Hachette have settled, but Apple, Pengin Group and Macmillan have not.

The DOJ settlement required that retailers must at least break even selling all ebooks from a publisher's available list, according to Coker and Joe Wikert, general manager and publisher at O'Reilly Media Inc.

It was not clear if EU regulators will include a similar requirement, which would prohibit Amazon from pricing all ebooks at a loss, said Wikert, a former publishing executive.

In the United States, Amazon will likely price popular titles at a loss and try to make up the difference on a publisher's other ebooks, he said.

Coker said any such rule could be dangerous in Europe, which still has distinct markets.

"It could allow a single retailer to charge full price in a large market like the U.K., and then sell below cost or for free in multiple smaller markets as a strategy to kill regional ebook retailing upstarts before they take root," Coker said.

FROWNING ON ONLINE TRADE CURBS

Antitrust regulators tend to frown on restrictions on online trade and the case is a good example, said Mark Tricker, a partner at Brussels-based law firm Norton Rose.

"This case shows the online world continues to be a major focus for the Commission," he said.

"These markets change very quickly and if you don't stamp down on potential infringements of competition rules, you can have significant consequences."

(Additional reporting by Alistair Barr in San Francisco; Editing by Rex Merrifield, David Goodman and David Gregorio)

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Methane warnings ignored before NZ mine disaster

WELLINGTON, New Zealand (AP) — A New Zealand coal mining company ignored 21 warnings that methane gas had accumulated to explosive levels before an underground explosion killed 29 workers two years ago, an investigation concluded.

The official report released Monday after 11 weeks of hearings on the disaster found broad safety problems in New Zealand workplaces and said the Pike River Coal company was exposing miners to unacceptable risks as it strove to meet financial targets.

“The company completely and utterly failed to protect its workers,” New Zealand Prime Minister John Key said Monday.

The country’s labor minister, Kate Wilkinson, resigned from her labor portfolio after the report’s release, saying she felt it was the honorable thing to do after the tragedy occurred on her watch. She plans to retain her remaining government responsibilities.

The Royal Commission report said New Zealand has a poor workplace safety record and its regulators failed to provide adequate oversight before the explosion.

At the time of the disaster, New Zealand had just two mine inspectors who were unable to keep up with their workload, the report said. Pike River was able to obtain a permit with no scrutiny of its initial health and safety plans and little ongoing scrutiny.

Key said he agrees with the report’s conclusion that there needs to be a philosophical shift in New Zealand from believing that companies are acting in the best interests of workers to a more proscriptive set of regulations that forces companies to do the right thing.

The commission’s report recommended a new agency be formed to focus solely on workplace health and safety problems. It also recommended a raft of measures to strengthen mine oversight.

Key said his government would consider the recommendations and hoped to implement most of them. He would not commit on forming a new agency. Workplace safety issues are currently one of the responsibilities of the Ministry of Business, Innovation and Employment.

In the seven weeks before the explosion, the Pike River company received 21 warnings from mine workers that methane gas had built up to explosive levels below ground and another 27 warnings of dangerous levels, the report said. The warnings continued right up until the morning of the deadly explosion.

The company used unconventional methods to get rid of methane, the report said. Some workers even rigged their machines to bypass the methane sensors after the machines kept automatically shutting down — something they were designed to do when methane levels got too high.

The company made a “major error” by placing a ventilation fan underground instead of on the surface, the report found. The fan failed after the first of several explosions, effectively shutting down the entire ventilation system. The company was also using water jets to cut the coal face, a highly specialized technique than can release large amounts of methane.

The report did not definitively conclude what sparked the explosion itself, although it noted that a pump was switched on immediately before the explosion, raising the possibility it was triggered by an electrical arc.

The now-bankrupt Pike River Coal company is not defending itself against charges it committed nine labor violations related to the disaster. Former chief executive Peter Whittall has pleaded not guilty to 12 violations and his lawyers say he is being scapegoated.

An Australian contractor was fined last month for three safety violations after its methane detector was found to be faulty at the time of the explosion.

Australia / Antarctica News Headlines – Yahoo! News

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Composer, Pulitzer winner Carter dies in NY at 103

NEW YORK (AP) — Classical composer Elliott Carter, whose challenging, rhythmically complex works earned him widespread admiration and two Pulitzer Prizes, died Monday at age 103.

His music publishing company, Boosey & Hawkes, called him an “iconic American composer.” It didn’t give the cause of his death.

In a 1992 Associated Press interview, Carter described his works as “music that asks to be listened to in a concentrated way and listened to with a great deal of attention.”

“It’s not music that makes an overt theatrical effect,” he said then, “but it assumes the listener is listening to sounds and making some sense out of them.”

The complex way the instruments interact in his compositions created drama for listeners who made the effort to understand them, but it made them difficult for orchestras to learn. He said he tried to give each of the musicians individuality within the context of a comprehensible whole.

“This seems to me a very dramatic thing in a democratic society,” he said.

While little known to the general public, he was long respected by an inner circle of critics and musicians. In 2002, The New York Times said his string quartets were among “the most difficult music ever conceived,” and it hailed their “volatile emotions, delicacy and even, in places, plucky humor.”

Carter had remained astonishingly active, taking new commissions even as he celebrated his 100th birthday in December 2008 with a gala at Carnegie Hall.

“I’m always proud of the ones I’ve just written,” he said at the time.

In 2005, his “Dialogues,” which had premiered the previous year, was a finalist for the Pulitzer Prize in music. And in 2006, his “Boston Concerto” was nominated for a Grammy Award as best classical contemporary composition.

Carter won his first Pulitzer Prize in 1960 for his Second String Quartet; his second award was in 1973 for his Third String Quartet. The Juilliard String Quartet chose to mark its 45th anniversary in 1991 with a concert of all four Carter string quartets. A fifth quartet came out in 1995.

When the first National Medal of Arts awards were given in 1985, Carter was one of 10 people honored, along with such legends as Martha Graham, Ralph Ellison and Georgia O’Keeffe. The awards were established by Congress in 1984.

The New Grove Dictionary of American Music said that at its best, Carter’s music “sustains an energy of invention that is unrivaled in contemporary composition.”

Carter said he found Europeans more receptive to his works than his fellow Americans because music in Europe is not purely entertainment but part of the culture, “something that people make an effort to understand.”

The lack of widespread attention didn’t seem to bother him.

“I don’t think it means anything to be popular,” he said. “When we see the popular tastes and the popular opinion constantly being manipulated by all sorts of different ways, it seems to me popularity is a meaningless matter.”

In 1992, Carter said his favorite piece of music was his Concerto for Orchestra, written in 1969. It was commissioned by the New York Philharmonic for its 125th anniversary season.

“It particularly expresses a picture of the United States as an evolving world of not only people but of nature,” he said.

Among his early works were two ballets, “The Minotaur” and “Pocahontas,” and his First Symphony. His First String Quartet in 1951 started him on the road to greater critical attention.

Besides composing, Carter wrote extensively about 20th-century music. A collection of articles, “The Writings of Elliott Carter: An American Composer Looks at Modern Music,” was published in 1977.

Carter as born in New York in 1908. As a young man he became acquainted with composer Charles Ives, who encouraged his ambitions. He studied literature at Harvard and then studied music in Paris under famed teacher Nadia Boulanger, who also guided Leonard Bernstein, Aaron Copland and Virgil Thompson.

As Carter turned 100, he recalled a visit to the hall in 1924 to see the New York premiere of Igor Stravinsky’s revolutionary work “The Rite of Spring.”

“I thought it was the greatest thing I ever heard, and I wanted to do like that, too,” Carter recalled. “Of course, half the audience walked out, which was even more pleasant to me. It seemed much more exciting than Beethoven and Brahms and the rest of them.”

In 1939, he married sculptor Helen H. Frost Jones. They had one son. He is survived by his son and a grandson.

Entertainment News Headlines – Yahoo! News

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Factbox: U.S. President Barack Obama

(Reuters) – As the 44th president of the United States, Barack Obama, 51, signed into law a revamp of the national healthcare system and authorized the raid that killed Osama bin Laden but struggled to revive the economy and create jobs.

As the United States holds its presidential election on Tuesday, here are key facts about Obama, the nation’s first black president.

- Barack Obama has a personal background like no other president in U.S. history. His mother, Ann Dunham, was a white woman from Kansas and his father, Barack Obama Sr., was a black Kenyan who saw little of his son after a divorce when the boy was a toddler. Obama spent much of his childhood in Indonesia and then Hawaii, where he lived with his maternal grandparents.

- Obama struggled with his mixed racial background while growing up, writing in a memoir that he wondered “if something was wrong with me.” He also was troubled by the absence of his father, whom he considered a “myth,” and said that may have contributed to his use of marijuana and cocaine in his youth.

- Obama graduated from New York’s Columbia University in 1983 and worked in the business sector in New York and for a Chicago community group. In 1988 he went to Harvard Law School, where he became the first black president of the prestigious Harvard Law Review.

- Obama’s relationship with Congress has been problematic. Even when Democrats controlled the House of Representatives and the Senate, Republicans often stymied his initiatives. The situation became more difficult when tax-averse Republicans took over the majority in the House in 2010.

- In the early 1990s Obama worked in a voter registration campaign in Chicago, taught constitutional law at the University of Chicago and joined a law firm that specialized in civil rights and neighborhood development. He married Michelle Robinson, whom he met at a law firm when he was an intern and she was assigned to be his adviser.

- In his rare spare moments, the lanky Obama pursues his lifelong love of basketball with semi-regular games at an FBI gym. He also makes time for school functions and sports events of his daughters Sasha and Malia and tries to get out for an occasional “date night” with his wife.

- Obama’s political career began with his election to the Illinois State Senate in 1996 and soared in 2004 when he gave a rousing keynote address at the Democratic National Convention. In November of that year he was elected to the U.S. Senate.

- Obama won the 2008 Democratic presidential nomination by defeating Hilary Clinton, the former first lady and New York senator, and then took the presidency by beating Republican Senator John McCain. His energetic campaign was built on a theme of “hope and change” fueled by powerful oratory.

- A mood of national optimism prevailed at Obama’s inauguration on January 20, 2009, which drew an estimated 1.8 million people to the National Mall in Washington despite bitter cold. He began his presidency with a 68 percent approval rating.

- Obama simultaneously oversaw wars in Iraq, which he ended in 2011, and Afghanistan, as well as the U.S. military involvement in Libya that helped oust Muammar Gaddafi. In May 2011 he authorized the raid in which U.S. Navy SEALS killed al Qaeda leader Osama bin Laden in Pakistan – a triumph he points to as indicative of a strong national security policy.

- Obama inherited an economic crisis so persistent that it remains a threat to his re-election. Almost 800,000 jobs were lost the month he took over. In the early days of his administration, he pushed through an $ 831 billion economic stimulus package and renewed loans to automakers, even making the government a temporary part-owner of General Motors.

- The centerpiece of his domestic agenda was the Affordable Care Act, the healthcare reform law better known as Obamacare. Its purpose is to give all Americans affordable insurance and more protections but critics say it is expensive federal interference. A key aspect of the reform – requiring most Americans to get insurance or pay a penalty – survived a 2012 U.S. Supreme Court challenge.

- Obama has a reputation as a charming communicator but he also is criticized for being aloof and not building better relationships with congressional leaders. Some have questioned his preparation skills, especially after a poor performance in a presidential debate with Republican opponent Mitt Romney.

(Writing by Bill Trott; editing by Christopher Wilson)

Seniors/Aging News Headlines – Yahoo! News

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Apple sells three million iPads over first weekend

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Newspaper discloses new Cameron text messages

LONDON (AP) — A British lawmaker says he’s asked the country’s media ethics inquiry to consider newly disclosed text messages sent between Prime Minister David Cameron and Rebekah Brooks, the ex-chief executive of Rupert Murdoch‘s British newspaper division.

The Mail on Sunday newspaper on Sunday published two previously undisclosed messages exchanged between the pair, who are friends and neighbors.

Brooks is facing trial on conspiracy charges linked to Britain’s phone hacking scandal, which saw Murdoch close down The News of The World tabloid.

In one newly disclosed message, Cameron thanked Brooks in 2009 for allowing him to borrow a horse, joking it was “fast, unpredictable and hard to control but fun.”

Opposition lawmaker Chris Bryant has asked a judge-led inquiry scrutinizing ties between the press and the powerful to examine the messages.

Europe News Headlines – Yahoo! News

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Despite storm damage, election officials in N.Y., N.J. remain hopeful

NEW YORK (AP) — Power generators are being marshaled, polling locations moved and voting machines hurriedly put into place as officials prepare to hold an national election in storm-ravaged sections of New York and New Jersey barely a week after Superstorm Sandy.

Organizers expressed guarded confidence Sunday that the presidential vote will proceed with no major disruptions in most areas hit by the storm, though it was unclear whether the preparations would be enough to avoid depressed turnout in communities where people still lack power or have been driven from their damaged homes.

Some voters will be casting ballots in places different from their usual polls.

In Long Beach, N.Y., a barrier-island city that was inundated with water during the storm, the number of polling places will be cut to four, down from the usual 11. Residents of the devastated borough of Sea Bright, on the New Jersey shore, will have to drive two towns over to vote.

But with two days to go until Election Day, officials in both states said Sunday that they were overcoming many of their biggest challenges.

Hundreds of emergency generators have been rushed into place to ensure power at polling places, even if the neighborhoods around them are still dark. Electric utilities were putting a priority on restoring power to others and had assured election officials they would be up and running by Monday.

Of the 1,256 polling locations in New York City, only 59 needed to be moved or closed, said Valerie Vazquez, a spokeswoman for the city's Board of Elections. Most were in coastal areas of Brooklyn and Queens or other neighborhoods where buildings normally used for voting had been turned into shelters.

Some New York City leaders remained worried. Mayor Michael Bloomberg noted that the polling-place changes would affect some 143,000 New Yorkers.

"Over the next day, it's going to be critical that the Board of Elections communicate this new information to their poll workers," he said.

The board, which is independent of the mayor's office, has historically had problems opening all voting locations on time, even in a normal year, the mayor noted.

Just east of the city, in Nassau County, Elections Commissioner William Biamonte warned that some voting locations would have a "paramilitary look," with portable toilets, emergency lighting and voting machines running off a generator.

As of Sunday morning, the county had 266,000 homes and business without power — more than anyplace else in the state. Some 30 to 40 polling locations, out of 375 in the county, were expected to be changed because of storm problems.

But Biamonte said he didn't expect that the problems would keep large numbers of people from casting ballots.

"I think people will be voting in less-than-optimal situations, but they will not be voting in a way that disenfranchises them," Biamonte said.

Yet for some residents of the hardest-hit areas, the hassle of having to travel even a few miles to find an open polling place was likely to be one burden too many.

William Agosto, who lost everything he owned when his basement apartment in the Far Rockaway area of Queens flooded, said he hoped to vote but couldn't guarantee he would have the energy or the time.

"I'm going to try," he said, clutching a garbage bag filled with donated clothing. "I have so much on my mind. What I'm going through, it's too much."

On Staten Island, where two polling locations were being relocated due to storm problems, bus driver Jim Holden said the election should be postponed.

"People can't get out to vote. Half these cars are under water," he said.

New Jersey residents driven from their homes by the storm were being given extra voting options. Registered voters will be able to apply for an absentee ballot by fax or email right through 5 p.m. on Election Day, and cast it via fax or email until 8 p.m. Displaced voters can also cast provisional ballots at any polling place in the state.

Monmouth County spokeswoman Laura Kirkpatrick said elections officials there had consolidated some polling locations and moved others, but expected to have working polls for all 53 municipalities come Election Day. She said the county was confident enough that it was encouraging people to vote in person, rather than scramble to file an absentee ballot by email.

"We are looking very good," she said.

Kirkpatrick said officials were somewhat concerned that residents might misunderstand the email voting option and try casting write-in ballots by sending messages to election officials, rather than go through the formal process of obtaining, signing and scanning an official ballot.

John Conklin, a spokesman for the New York Board of Elections, said some counties were training additional poll workers. The companies that make the state's electronic voting machines had sent scores of generators from other parts of the country to ensure enough power. And each polling location will be able to switch to paper ballots, if there is an unexpected loss of power on Election Day.

Utility companies in Connecticut promised that all polling places in that state would have power Tuesday.

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Angioplasty costs are higher at non-surgery hospitals

LOS ANGELES (Reuters) – Angioplasty to clear blocked arteries costs more at hospitals not equipped for emergency heart surgery, according to a study presented on Sunday at the American Heart Association scientific meeting.

Elective angioplasty is becoming increasingly common at hospitals that do not conduct more complicated heart procedures. During angioplasty, doctors insert a balloon-tipped catheter into an artery and inflate a balloon to open the narrowed blood vessel.

Researchers from Duke University Medical School in North Carolina analyzed billing data from more than 18,000 patients and found that the average cumulative medical costs were $ 23,991 in surgery-equipped hospitals, versus $ 25,460 in those without surgical centers.

“Surprisingly, there was no difference in procedure cost,” said Dr. Eric Eisenstein, lead author of the study and assistant professor of medicine at Duke. “We did find a difference in follow-up cost.”

The difference was due mainly to the fact that non-surgery hospitals used intensive care units for post-angioplasty care, as required by the study, and patients treated at these hospitals were more likely to be readmitted nine months after treatment.

“Rising costs of medical care make it very pertinent for us to assess value,” said Dr. Mark Hlatky, director of the cardiovascular outcomes research center at Stanford University.

Eisenstein said, “there is no guarantee that a community hospital can provide angioplasty services at costs comparable with those of major hospitals with on-site cardiac surgery.”

More than 1 million coronary artery opening procedures are performed in the United States each year, according to the American Heart Association.

(Reporting By Deena Beasley; Editing by Stacey Joyce)

Health News Headlines – Yahoo! News

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Google's Android software in 3 out of 4 smartphones

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