Boehringer Ingelheim to start late-stage hepatitis C drug trial
















BOSTON (Reuters) – Boehringer Ingelheim said on Saturday it plans to initiate a late-stage clinical trial of its experimental hepatitis C treatment following promising results from earlier studies.


The company announced final data from a mid-stage trial of its treatment regimen which showed that 69 percent of patients in the study were free of the virus 12 and 24 weeks following the end of treatment.













Hepatitis C is a blood-borne infectious disease of the liver that can lead to liver failure and transplant.


Historically, hepatitis C has been treated with pegylated interferon and ribavirin, but treatment lasts as long as 48 weeks and interferon is associated with flu-like side effects.


The goal of drugmakers now, including Boehringer, Vertex Pharmaceuticals Inc, Gilead Sciences Inc and Bristol-Myers Squibb Co is to develop products that do not need to be combined with interferon. Most analysts consider Gilead to currently be at the forefront of the race.


Full results from Boehringer’s trial, known as SOUND-C2, were presented at the annual meeting of the American Association for the Study of Liver Diseases in Boston. Preliminary data were presented earlier this year.


Boehringer’s trial tested a combination of BI-201335, a protease inhibitor, BI-207127, a polymerase inhibitor, and ribivirin.


Boehringer is a privately held company headquartered in Ingelheim, Germany.


(Reporting By Toni Clarke; Editing by Marguerita Choy)


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Ohio teen gets prison for life in Craigslist murders
















AKRON, Ohio (Reuters) – Seventeen-year-old Brogan Rafferty was sentenced to life in prison without parole Friday for his role in the killing of three men, two of whom were lured by a Craigslist ad promising work on an Ohio farm.


Rafferty was 16 when he was arrested in November 2011, but was tried as an adult. He was convicted late last month in the murders of David Pauley, 51, of Norfolk, Virginia; Ralph Geiger, 56, of Akron, Ohio; and Timothy Kern, 47, of Massillon, Ohio.













Rafferty also got 10 years for the attempted murder of Scott Davis, who was shot in the arm while escaping after meeting Rafferty and alleged triggerman Richard Beasley.


Prosecutors called the teen an apt pupil to Beasley, 53, who is also charged in the murders.


Rafferty testified that he was terrified of the man he had considered a father figure and spiritual adviser after he saw Beasley shoot Geiger in the head execution-style.


Beasley allegedly enticed Geiger with the offer of a non-existent caretaker job, killed him, stole his identity, and then drew other victims by posting the bogus job on Craigslist.


Rafferty, wearing prison stripes with hands clasped in front of him, told the court Friday that Beasley an “evil, deceitful cruel murderer,” but admitted the he bore some responsibility.


“I was involved, I didn’t like it, and now I see there were many options I couldn’t see then that I see now, but I can’t make anything better and I’m sorry,” he said.


Judge Lynn Callahan called Rafferty’s case “heartbreaking” but said she did not accept that he had no way out of his situation.


“You embraced the evil, you studied it,” she said. She said Rafferty had been dealt “a lousy hand in life,” but she found nothing in the case that could be chalked up to the recklessness of youth.


“You could have been so much more; you are so intelligent,” the judge told Rafferty.


During the trial, jurors heard testimony that the teen helped dig graves for some of the men and was found in possession of guns and knives stolen from them after Beasley shot them.


Beasley’s trial is scheduled in the same courtroom for January 7. He faces the death penalty if convicted. Both Rafferty’s and Beasley’s attorneys are under a gag order and are not permitted to talk to the media.


Under Ohio law, juveniles older than 15 who are charged with a serious offense and crimes that involve a firearm are sent to adult court for trial.


Last summer, a U.S. Supreme Court decision struck down mandatory life sentences for juveniles. The high court found that judges and juries passing sentence on juvenile murders must weigh mitigating circumstances, including the youth’s role and family background.


A 2005 Supreme Court decision made it unconstitutional to execute anyone under the age of 18.


Rafferty’s attorney Jill Flagg objected to his sentence and will appeal.


In other incidents involving Craigslist and other social media, people advertising goods for sale or responding to ads have been attacked and killed.


In 2009, a former medical student was accused of killing a masseuse he met through Craigslist. In February, two men in Tennessee were accused of killing a man and a woman for “unfriending” the daughter of one of the suspects on Facebook.


(Reporting by Kim Palmer; Editing by Mary Wisniewski and Eric Walsh)


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Syria opposition bloc elects Christian as leader
















DOHA, Qatar (AP) — Syria‘s main opposition group in exile has elected a Christian Paris-based former geography teacher as its new president.


George Sabra said Friday that his election as head of the Syrian National Council is a sign that the opposition is not plagued by sectarian divisions.













Sabra says the SNC‘s main demand is to receive weapons from the international community. The U.S. and some other foreign backers of rebels fighting the regime of President Bashar Assad have so far refused to send weapons for fear they can fall into the wrong hands.


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Was Petraeus affair linked to lax Libya response?

CIA Director David Petraeus abruptly resigned Friday, citing an extramarital affair and the need to sort out the “personal and professional issues” involved.


The former commander of forces in Iraq and Afghanistan had built a stellar and nearly unassailable reputation – but mounting criticism of the Central Intelligence Agency’s response to the Benghazi, Libya, terrorist attack in September was beginning to tarnish that reputation.


Word of Mr. Petraeus’s resignation sent ripples of stunned surprise through both the intelligence and military communities, raising questions that revolved around how long the affair had been going on and how an officer known for his rigorous self-discipline – and attention to his reputation within the media — could have made such a lapse in judgment.


RECOMMENDED: 5 ways events overseas could shape Obama's second term


In a letter of resignation accepted by the White House, Petraeus said he had been married 37 years but had exercised “very poor judgment” in choosing to enter into an extramarital affair.


Petraeus, who was widely celebrated as a military commander and even occasionally mentioned as a potential presidential candidate, was sworn in as head of the CIA in September 2011 – and had kept a low profile since. Now speculation is sure to proliferate over whether that low profile resulted from Petraeus focusing on America’s intelligence gathering or on personal matters.


In particular, members of Congress and other officials demanding answers about the Benghazi attack on the US consulate that resulted in the deaths of four Americans – including the US ambassador to Libya, Christopher Stephens, and two CIA agents – will want to know if there was any link between Petraeus’s extramarital activities and what has been increasingly criticized as the CIA’s weak performance on the night of the Benghazi attack.


More broadly, the reason for Petraeus’s departure will raise questions about any compromising of US covert operations and intelligence. The potential for blackmail of intelligence officers is always a concern about the spy corps, but the involvement of the nation’s top spy in an extramarital affair takes the concern to a new level.


The Federal Bureau of Investigation has been probing Petraeus and the potential security risks posed by his affair, CNN reported late Friday afternoon.


In the weeks since the Benghazi attack, officials have leaked information, including how Petraeus kept information on the CIA’s role in Benghazi so private that even Secretary of State Hillary Rodham Clinton was left to call Petraeus as the attack unfolded to try to get intelligence information from him.


Last week, CIA officials revealed that in fact, the intelligence agency’s operations in Benghazi dwarfed diplomatic operations at the consulate and that the CIA maintained what was described as an “annex,” about a mile from the diplomatic mission.


State Department officials have said there was an informal understanding that the annex and its agents would come to the assistance of the consulate (which had private contractors providing security) if a need arose. CIA officials insist their agents responded to the consulate’s distress calls within a half-hour.


In a statement released Friday afternoon, President Obama praised Petraeus for his “extraordinary service” to the country, adding, “By any measure, through his lifetime of service, David Petraeus has made our country safer and stronger.”


In a statement, Sen. John McCain (R) of Arizona highlighted Petraeus’s role in Iraq, saying that his “inspirational leadership and his genius were directly responsible – after years of failure – for the success of the surge in Iraq.”


But Petraeus’s success in Iraq and Afghanistan was a result to a certain extent of his focus on a counterinsurgency strategy that involved large numbers of troops fighting the enemy by incorporating nation-building into the battle. When Mr. Obama named Petraeus to head the CIA, it was widely interpreted as the president’s signal that he intended to wind down America’s wars and shift from a counterinsurgency strategy to counterterrorism.


Obama did not cite Petraeus’s reason for resigning but did say, “Going forward, my thoughts and prayers are with Dave and Holly Petraeus, who has done so much to help military families through her own work. I wish them the very best at this difficult time.”


Mrs. Petraeus is the assistant director of the Consumer Financial Protection Bureau, where she supports veterans and troops facing difficulties as a result of the financial crisis.


Obama initially tried to convince Petraeus not to resign, according to some souces. “I am told that President Obama tried to talk Petraeus out of resigning, but Petraeus took the samurai route and insisted that he had done a dishonorable thing and now had to try to balance it by doing the honorable thing and stepping down as CIA director,” Tom Ricks reports in his blog “The Best Defense.”


Such a move is in keeping with the military culture in which Petraeus rose to the rank of four-star general.


Under the Uniform Code of Military Justice, adultery is a punishable offense for soldiers if the conduct is shown to be detrimental “to good order and discipline in the armed forces or was of a nature to bring discredit upon the armed forces.”


Obama said that Michael Morell, deputy director of the CIA, would take over as acting director. Mr. Morell served briefly as acting director after Leon Panetta left the agency last year to become Defense secretary.


Petraeus was set to testify Thursday at a closed-door session of the Senate Intelligence Committee on the Benghazi attack, but it was unclear if his resignation would alter that schedule.


Sen. Dianne Feinstein (D) of California, the Intelligence Committee chair, told NBC News that Petraeus’s personal mistake should not have led to his resignation.


“I would have stood up for him,” she said. “I wanted him to continue. He was good, he loved the work, and he had a command of intelligence issues second to none.”


Obama, after winning reelection Tuesday, was already expected to make some changes in his national security team for a second term, but early speculation had been that Petraeus would stay on at the CIA. Now the job of spy chief will be added to the new-team mix.


RECOMMENDED: 5 ways events overseas could shape Obama's second term



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Taylor Swift to headline “New Year’s Rockin’ Eve”
















LOS ANGELES (Reuters) – Country-pop star Taylor Swift will ring in the New Year in the United States as the headline act on TV special “New Year’s Rockin’ Eve,” which will feature a two-hour tribute to late host Dick Clark, organizers said on Friday.


Swift, whose new album “Red” racked up more than 1 million copies in first week U.S. sales, will perform live in New York’s Times Square on December 31, just before the ball drops to bring in 2013.













The New Year’s Eve music special for ABC television was hosted for four decades by legendary TV and music producer Clark before his death in April at age 82.


This year the show will be helmed again by Clark’s recent co-host – “American Idol” host and radio DJ Ryan Seacrest – under the title “Dick Clark’s New Year’s Rockin’ Eve with Ryan Seacrest,” ABC and dick clark productions said.


The evening will kick off with a two-hour tribute to the host of TV dance show “American Bandstand” that will feature clips of Clark’s long career, and remembrances by musicians and industry celebrities.


The 5-1/2 hour show will also feature other musical guests, yet to be announced, and report on New Year celebrations around the globe.


(Reporting By Jill Serjeant; Editing by Eric Walsh)


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California teen steps into rattlesnake nest, survives
















SAN DIEGO (Reuters) – A teenage California girl searching for a cell phone signal to call her mother in a rural area outside San Diego inadvertently stepped into a nest of rattlesnakes and was bitten six times, but survived.


The 16-year-old, Vera Oliphant, spent four days in the intensive care unit of Sharp Grossmont Hospital, and doctors gave her 24 vials of antivenom after she was bitten by an adult rattlesnake and five young rattlers outside her uncle’s home.













“I was trying to find a signal to call my mom and text my boyfriend,” Oliphant said on Friday, a day after she was released from the hospital following the October 27 incident.


“I didn’t see them until I already stepped on their nest and I felt them biting me.”


“My vision started to go right away. First it looked like the snakes blended into the leaves and then I started seeing black spots around the edges and I started blacking out.”


She returned to her uncle’s home in Jamul, outside San Diego, and he immediately packed her into the car and rushed her to the emergency room, she said.


On the way, she talked to her mom and her boyfriend, who told her to stay calm so the venom wouldn’t spread.


“I told my mom and my boyfriend I love them in case I don’t get to see them again,” she said.


Doctors there administered 24 vials of antivenom to quash the dangerous toxins, according to a hospital spokesman. Snakebites usually aren’t fatal, although a handful of people die in the United States each year from snake bites, including bites from rattlesnakes.


Oliphant has recovered and will be returning to classes at Chaparral High School in El Cajon on Monday. She said the next time she can’t get a signal, she will handle it differently.


“Be careful where you step,” she said. “If you don’t need to, just wait until you are somewhere that you can call people.”


(Editing By Cynthia Johnston and Todd Eastham)


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Spotify to raise $100 million at $3 billion valuation – report
















(Reuters) – Spotify is in the middle of a $ 100 million financing round that could value the music streaming company at just over $ 3 billion, the Wall Street Journal reported citing sources.


The Journal said Spotify would raise the fresh capital from multiple investors including Goldman Sachs. The WSJ report did not name any other investors.













Spotify has raised capital from outside investors several times since it set up shop in 2006, and was earlier reported to have been looking to secure a capital boost of about $ 200 million, at a valuation of about $ 4 billion.


Kleiner Perkins Caufield & Byers, Accel Partners and others have invested about $ 189 million in the company in its prior financing rounds.


The company has over 15 million active users and 4 million paying subscribers, for its on-demand service, which offers unlimited music streaming of some 18 million tracks.


(Reporting by Himank Sharma in Bangalore)


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Myanmar says Obama to visit later this month
















YANGON, Myanmar (AP) — President Barack Obama will make a groundbreaking visit later this month to Myanmar, an official said Thursday, following through with his policy of rapprochement to encourage democracy in the Southeast Asian nation.


The Myanmar official speaking from the capital, Naypyitaw, said Thursday that security for a visit on Nov. 18 or 19 had been prepared, but the schedule was not final. He asked not to be named because he was not authorized to give information to the media.













The official said Obama would meet with opposition leader Aung San Suu Kyi as well as government officials including reformist President Thein Sein.


It would be the first-ever visit to Myanmar by an American president. U.S. officials have not yet announced any plans for a visit, which would come less than two weeks after Obama’s election to a second term.


Obama’s administration has sought to encourage the recent democratic progress under Thein Sein by easing sanctions applied against Myanmar’s previous military regime.


Officials in nearby Thailand and Cambodia have already informally announced plans for visits by Obama that same week. Cambodia is hosting a summit meeting of the Association of Southeast Asian Nations, and Thailand is a longtime close U.S. ally.


The visit to Myanmar, also known as Burma, would be the culmination of a dramatic turnaround in relations with Washington as the country has shifted from five decades of ruinous military rule and shaken off the pariah status it had earned through its bloody suppression of democracy.


Obama’s ending of the long-standing U.S. isolation of Myanmar’s generals has played a part in coaxing them into political reforms that have unfolded with surprising speed in the past year. The U.S. has appointed a full ambassador and suspended sanctions to reward Myanmar for political prisoner releases and the election of Nobel laureate Suu Kyi to parliament.


From Myanmar’s point of view, the lifting of sanctions is essential for boosting a lagging economy that was hurt not only by sanctions that curbed exports and foreign investment, but also by what had been a protectionist, centralized approach. Thein Sein’s government has initiated major economic reforms in addition to political ones.


A procession of senior diplomats and world leaders have traveled to Myanmar, stopping both in the remote, opulent capital city, which was built by the former ruling junta, and at Suu Kyi’s dilapidated lakeside villa in the main city of Yangon, where she spent 15 years under house arrest. New Zealand announced Thursday that Prime Minister John Key would visit Myanmar after attending the regional meetings in Cambodia.


The most senior U.S. official to visit was Hillary Rodham Clinton, who last December became the first U.S. secretary of state to travel to Myanmar in 56 years.


The Obama administration regards the political changes in Myanmar as a marquee achievement in its foreign policy, and one that could dilute the influence of China in a country that has a strategic location between South and Southeast Asia, regions of growing economic importance.


But exiled Myanmar activists and human rights groups are likely to criticize an Obama visit as premature, rewarding Thein Sein before his political and economic reforms have truly taken root. The military — still dominant and implicated in rights abuses — has failed to prevent vicious outbreaks of communal violence in the west of the country that have left scores dead.


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Obama breaks down while speaking to staff, volunteers



The morning after he won re-election, an emotional President Barack Obama credited his youthful staff of several hundred with running a campaign that will "go on in the annals of history."



"What you guys have accomplished will go on in the annals of history and they will read about it and they'll marvel about it," said Obama told his team Wednesday morning inside the Chicago campaign headquarters, tears streaming down his face.



"The most important thing you need to know is that your journey's just beginning. You're just starting. And whatever good we do over the next four years will pale in comparison to whatever you guys end up accomplishing in the years and years to come," he said.



The moment, captured by the Obama campaign's cameras and posted online, offers a rare glimpse at the president unplugged and emotional. During the first four years of his presidency, Obama has never been seen publicly crying.



He first came to Chicago, he told the campaign staff, "knowing that somehow I wanted to make sure that my life attached itself to helping kids get a great education or helping people living in poverty to get decent jobs and be able to work and have dignity. And to make sure that people didn't have to go to the emergency room to get health care."



"The work that I did in those communities changed me much more than I changed those communities because it taught me the hopes and aspirations and the grit and resilience of ordinary people," he said, as senior strategist David Axelrod and campaign manager Jim Messina looked on. "And it taught me the fact that under the surface differences, we all have common hopes and we all have common dreams. And it taught me something about how I handle disappointment and what it meant to work hard on a common endeavor, and I grew up."



"So when I come here and I look at all of you, what comes to mind is, it's not that you guys remind me of myself, it's the fact that you are so much better than I was in so many ways. You're smarter, you're so better organized, you're more effective," he said.



Obama said he expected many of those who helped to re-elect him will assume new roles in progressive politics, calling that prospect a "source of my strength and inspiration."



Senior campaign officials said Thursday that the Obama campaign infrastructure - the field offices and network of hundreds of thousands of volunteers - would undergo a period of transition in the coming weeks to determine how to remain sustainable and influential.



"We have remarkable staff, and the campaign that Jim [Messina] put together, you know, is the best in history," said senior Obama adviser David Plouffe. "But the reason those people got involved was because they believed in Barack Obama. It was the relationship between them and our candidate."


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Lagerfeld says Ghesquiere with Arnault “not bad idea”
















PARIS (Reuters) – Star designer Karl Lagerfeld said the departure of Nicolas Ghesquiere from Balenciaga as artistic director to create his own brand with backing from LVMH‘s Bernard Arnault would “not be a bad idea” as the group owned many old labels.


“Perhaps Nicolas wants to have his own label, which is not a bad idea,” Lagerfeld told Reuters in an interview on Thursday.













“And it would not be a bad idea if somebody such as Bernard Arnault would invest in a new label because there are so many old labels (within the LVMH group),” Lagerfeld said about the chief executive of the world’s biggest luxury group.


PPR, the French group which owns Balenciaga, shocked the fashion world by announcing this week the departure of Ghesquiere, who had been with the brand since 1997 and was the main architect of its revival.


The International Herald Tribune reported this week that one option for Ghesquiere was to create his own brand with the backing of Arnault, who controls LVMH, the world’s biggest luxury group, which owns many fashion brands including Louis Vuitton, Fendi and Celine.


Founded by Cristobal Balenciaga in 1919, his eponymous brand thrived until the late 1960s and then lay dormant until Ghesquiere took over as designer. The brand started to expand worldwide after PPR acquired it in 2001.


Balenciaga did not explain Ghesquiere’s departure clearly when it made the announcement on Monday but it suggested the designer was longing for a new creative adventure.


Lagerfeld, who runs his own brand on top of working as artistic director for LVMH’s Fendi and for privately owned Chanel, said he could not think about the succession.


“We (my team and I) only think in terms of one collection after the next collection,” he said. “In fashion, I am very much against projection in the far away future.”


Lagerfeld was speaking at the opening of an exhibition at the Grand Palais in Paris of his photos of celebrities themed around Chanel’s “little black jacket,” who were styled by Carine Roitfeld, former editor of the French Vogue.


The celebrities include artist Yoko Ono, John Lennon’s widow, film maker Sofia Coppola and actresses Kirsten Dunst and Milla Jojovich.


“I am happy I can do both fashion and photography because there is a link between the two but it is a link which I refuse to analyze,” Lagerfeld said.


PAVLOVSKY


Also present at the exhibition’s opening was Bruno Pavlovsky, president of Chanel’s fashion division, who like Lagerfeld would not be drawn too long on the subject of the designer’s succession.


“Karl is in great shape, I work every day with him and I can assure you that he is doing very well,” Pavlovsky said, adding that relations between Chanel and him had always been excellent.


“Of course one day there will be an after-Karl but Karl will have made Chanel so strong, with such strong codes that Chanel will find solutions,” Pavlovsky said.


The executive said Chanel, owned by the Wertheimer family, was doing well overall and expected 2012 to be another “good year” in spite of the global downturn which has affected many of its rivals including LVMH, Burberry and Gucci owner PPR.


However, he said the Chinese market was becoming more mature with growth levels in big cities such as Shanghai or Beijing becoming similar to that of European capitals or New York where Chanel has been for decades.


“We are no longer in the 20-30 percent growth levels we had seen (in previous years in China),” he said. “It can be more than 10 percent,” he said, referring to growth levels in big European cities.


Pavlovsky said Chanel planned to finish the year with 10 boutiques in China and 182 globally.


(Reporting by Astrid Wendlandt; Editing by Phil Berlowitz)


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